1) What creates the monsters in the novel from a scientific standpoint? What about from a superstitious standpoint? How do these two systems intersect, and what do they have to tell us about how monsters are created? 

2) What is the significance of the title? Would the meaning have changed if the book was called "I Am a Legend"? How does Robert Neville become a legend? 

3) Why does the new society in the book decide to kill Robert Neville? What does their decision to kill him reflect about their new society?
4) Robert Neville sees himself as superior to the new society's methods and motives and morals. Is he really? He also sees Ruth as a coldhearted messenger, particularly when she points out some things about himself he would rather not see. Is she really coldhearted? (Look at the final few pages of the novel). 
5) How might we connect the significance of the ending of the novel to Robert Neville's identity as a white male in the 1950s, pre-Civil Rights era?